"Among people now practicing calorie restriction, he says side effects include reduced libido because calorie restriction reduces testosterone levels. They also tend to become cold more quickly because their thermal regulation changes as their metabolism slows and their core body temperature drops."
Anybody notice these side effects? Reduced libido???
--- In fast5@yahoogroups.com, "tamaratornado" <tamaratornado@...> wrote:
>
> Science News
>
> Calorie Restriction Leads Scientists to Molecular Pathways That Slow Aging, Improve Health
>
> Science Daily (Apr. 15, 2010) —
>
> Organisms from yeast
> to rodents to humans all benefit from cutting calories. In
> less complex organisms, restricting calories can double or
> even triple lifespan. It's not yet clear just how much
> longer calorie restriction might help humans live, but those
> who practice the strict diet hope to survive past 100 years old.
>
>
> In a review article in the April 16 edition of Science,
> nutrition and longevity researchers at Washington University
> School of Medicine in St. Louis, University College in London and
> the Andrus Gerontology Center at the University of Southern
> California, report that calorie restriction influences the same
> handful of molecular pathways related to aging in all the animals
> that have been studied.
>
> Aware of the profound influence of calorie restriction on
> animals, some people have cut their calorie intake by 25 percent
> or more in hopes of lengthening lifespan. But first author Luigi
> Fontana, MD, PhD, is less interested in calorie restriction for
> longer life than in its ability to promote good health throughout
> life.
>
> "The focus of my research is not really to extend lifespan to 120
> or 130 years," says Fontana, research associate professor of
> medicine at Washington University and an investigator at the
> Istituto Superiore di Sanità in Rome, Italy. "Right now, the
> average lifespan in Western countries is about 80, but there are
> too many people who are only healthy until about age 50. We want
> to use the discoveries about calorie restriction and other
> related genetic or pharmacological interventions to close
> that 30-year gap between lifespan and 'healthspan. '
> However, by extending healthy lifespan, average lifespan
> also could increase up to 100 years of age."
>
> Fontana and his co-authors write about how cutting calorie intake
> between 10 percent and 50 percent decreases the activity of
> pathways involving insulin-like growth factor (IGF-1), glucose
> and TOR (target of rapamycin), and considerably increases
> lifespan in animals.Genetic mutations involved in those
> pathways have the same effect. Those animals have far fewer
> problems with diseases related to aging, such as cancer,
> cardiovascular disease and cognitive problems.
>
> "About 30 percent of the animals on calorie restriction die at an
> advanced age without any diseases normally related to aging,"
> Fontana says. "In contrast, among animals on a standard diet, the
> great majority (94 percent) develop and die of one or more
> chronic diseases such as cancer or heart disease. In 30
> percent to 50 percent of the animals on calorie
> restriction, or with genetic mutations in these
> aging-related pathways, healthspan is equal to lifespan.
> They eventually die, but they don't get sick."
>
> Unfortunately, many humans are moving in the opposite direction.
> As obesity reaches epidemic rates in Western countries, Fontana
> says rather than closing the 30-year gap between healthspan and
> lifespan, the gap is likely to grow. It's even possible lifespan
> may decrease as people develop preventable diseases such as
> atherosclerosis, type 2 diabetes and certain forms of cancer.
>
> Those growing rates of obesity are a reason some scientists think
> calorie restriction will never catch on, regardless of its
> potential benefits. But, Fontana says, if researchers who study
> nutrition and aging can understand how calorie restriction
> lengthens life and makes people healthier, it may be possible to
> develop less drastic interventions or medicines that influence
> pathways affected by calorie restriction and help keep people
> healthy as they get older.
>
> Among people now practicing calorie restriction, he says side
> effects include reduced libido because calorie restriction
> reduces testosterone levels. They also tend to become cold
> more quickly because their thermal regulation changes as
> their metabolism slows and their core body temperature
> drops.
>
> Fontana says as calorie restriction research advances on many
> fronts, it's becoming clear that dietary advice once based on
> epidemiological data now makes sense from a molecular point of
> view. In the past, dietitians might recommend more fruits and
> vegetables or less meat and more whole grains. They based that
> advice on studies showing people who ate more vegetables or fewer
> animal products tended to have less cardiovascular disease.
>
> "Now we have moved from epidemiology to molecular biology," he
> says. "We know that certain nutrients, as well as lower calorie
> intake, can influence IGF-1 and other pathways. Soon we hope to
> be able to use that knowledge to help people live longer
> and healthier lives.
>
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> 2.
> Key Protein May Explain The Anti-aging And Anti-cancer Benefits Of D
> Posted by: "Domingo" dpichardo3@... harrygton_oliver
> Tue Dec 21, 2010 5:18 am (PST)
>
>
>
> http://www.scienced aily.com/ releases/ 2009/05/09052208 1214.htm
> <http://www.scienced aily.com/ releases/ 2009/05/09052208 1214.htm>
>
> Key Protein May Explain The Anti-Aging And Anti-Cancer
> Benefits Of Dietary Restriction
> ScienceDaily (May 26, 2009) — A protein that plays a
> key role in tumor formation, oxygen metabolism and
> inflammation is involved in a pathway that extends lifespan
> by dietary restriction. The finding, which appears in the
> May 22, 2009 edition of the online journal PLoS Genetics,
> provides a new understanding of how dietary restriction
> contributes to longevity and cancer prevention and gives
> scientists new targets for developing and testing drugs that
> could extend the healthy years of life.
>
> The protein is HIF-1 (hypoxia-inducible factor 1). It helps cells
> survive by "turning on" when oxygen levels are low. HIF-1 is also
> active in some forms of human cancer. HIF-1 overexpression is
> frequently detected in solid tumors; inhibition of HIF-1 has been
> proved to be an efficient way to prevent cancer growth. Now,
> scientists at the Buck Institute for Age Research have shown that
> HIF-1 is also a key player in dietary restriction. HIF-1 is
> involved in a molecular pathway known to regulate cell growth and
> metabolism in response to nutrients and growth factors.
>
> "Previous studies on HIF-1 have mainly focused on its roles in
> oxygen metabolism and tumor development" , said Buck faculty
> member Pankaj Kapahi, PhD, lead author of the study.
>
> Kapahi says the study encourages the investigation of HIF-1 in
> nutrient sensing pathways. "The data in this study also points to
> HIF-1 as a likely target for regulating the protective effects of
> dietary restriction in mammals," said Kapahi.
>
> "Dietary restriction is one of the most robust methods for
> extending lifespan and delaying age-related disease among various
> species."
>
> Kapahi says the molecular mechanisms involved in how dietary
> restriction slows cancer and extends lifespan have been largely
> unknown. "This study gets us closer to understanding that process
> and gives us better targets for both designing and testing drugs
> which could mimic the effects of dietary restriction in humans,"
> said Kapahi.
>
> The research involved nematode worms that were genetically
> altered to both under and over-express HIF-1. The animals, which
> are the most-often used model to study aging, were fed different
> diets. Animals that were designed to over-express HIF-1 did not
> get the benefit of lifespan extension even though their diets
> were restricted. Animals that under-expressed HIF-1 lived
> longer, even when they had a nutrient-rich diet.
> Furthermore, it was found that the lifespan extension
> resulting from dietary restriction required activity in
> signaling pathways in the endoplasmic reticulum, the part
> of the cell involved in processing and the proper folding of
> proteins. This finding supports the theory that aging stems from
> the effects of misfolded proteins and opens up a rich area of
> investigation to examine the mechanisms by which stress in the
> endoplasmic reticulum affects lifespan.
>
> Other Buck Institute researchers involved in the study include Di
> Chen, and Emma Lynn Thomas. The work was supported by the Ellison
> Medical Foundation, the Larry L. Hillblom Foundation, the
> American Federation for Aging Research, the Bill and Rita
> Haynes Foundation, and the National Institute on Aging.
>
> http://www.sciencedaily.com/releases/2010/04/100415141123.htm
>
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