This is an interesting article because it discusses common migraines. It
also discusses the actual genes and alleles and mechanics they are
triggering. There is also a mention, kind of a hint of how this gene could
link migraine to seizure.
First gene link to common migraine
Gene detectives on Sunday announced they had found the first inherited link
to common types of migraine, a finding that boosts hopes for new drugs to
curb this painful and costly disorder.
-snip-
"This is the first time we have been able to peer into the genomes of many
thousands of people and find genetic clues to understand common migraine,"
said <http://topics.breitbart.com/Aarno+Palotie/> Aarno Palotie, head of
the
<http://topics.breitbart.com/International+Headache+Genetics+Consortium/>
International Headache Genetics Consortium at
<http://topics.breitbart.com/Britain/> Britain's
<http://topics.breitbart.com/Wellcome+Trust+Sanger+Institute/> Wellcome
Trust Sanger Institute, which led the study.
-snip-
The tiny genetic variant, or allele, is called rs1835740.
Lying on Chromosome 8 between two genes, PGCP and MTDH/AEG-1, it allows a
messenger chemical called glutamate to accumulate in junctions between
<http://topics.breitbart.com/brain+cells/> brain cells, and this unleashes
the migraine, the scientists believe.
-snip-
The <http://topics.breitbart.com/UN/> UN's
<http://topics.breitbart.com/World+Health+Organisation/> World Health
Organisation (WHO) ranks migraine in the top 20 diseases in terms of "years
lived with disability," a benchmark of handicap. A US estimate put
migraine's economic cost on a par with diabetes.
-snip-.
The study found rs1835740 to be one of several connecting genetic cogs in
regulating glutamate levels.
The allele alters the MTDH/AEG-1 gene, which in turn affects a gene called
EAA2.
The EAAT2 gene controls a protein that is responsible for clearing glutamate
from the brain synapses. This protein has previously been linked with
epilepsy, schizophrenia and various mood and anxiety disorders.
The authors say further work is needed to confirm the findings and see
whether other genetic culprits abound.
Patients in the study were recruited mainly from specialist headache
clinics, which means they are likely to represent only the more extreme end
of those who suffer from common migraines, said
<http://topics.breitbart.com/Gisela+Terwindt/> Gisela Terwindt of
<http://topics.breitbart.com/Leiden+University+Medical+Centre/> Leiden
University Medical Centre, <http://topics.breitbart.com/the+Netherlands/>
the Netherlands.
"In the future, we should look at associations across the general
population, including also people who are less severely affected," she said.
Migraine is believed to occur when inflammatory chemicals are released
around the nerves and blood vessels in the head, inducing pain that can be
excruciating. It is sometimes accompanied by nausea and hyper-sensitivity to
light and sound.
Common migraines fall into two categories -- those with an "aura," or
shimmering circle seen by the sufferer, and those without.
Sufferers tend to be aged 35-45, although the frequency and duration of the
attacks can very widely.
http://www.breitbart.com/article.php?id=CNG.3aaba8b91b0cf13472d553e2fd7a00be
.201
<http://www.breitbart.com/article.php?id=CNG.3aaba8b91b0cf13472d553e2fd7a00b
e.201&show_article=1> &show_article=1
In Christ,
Nedra 2 of 5,
Borg Mom Resistance is Futile in finding what works for my kids with God's
help
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