Hi Liz
I would say (for me anyway), it was the whole bit all rolled into one that found little bits of depression
here and there. AED's we are on do depress the nervous system, as again while really bad heck I couldn't care
less what anyone said, felt what happened or anything. Try to go off the meds is another thing and where it
really hits, then you feel like you have to have so you don't get these feelings. It is not the meds only but
the state our seizures leave our brain in. +/Or should we try and add over the counter meds of any kind along
with them. Once our AED's are in our brains they just love to control what else goes in there, or our body
period.
Just my 2 cents worth here.
Julie
Julie Hope
epilepsyhealth@sasktel.net
----- Original Message -----
From: "Elizabeth Quinn" <equinn76@earthlink.net>
To: <epilepsy@yahoogroups.com>
Sent: Sunday, January 01, 2012 2:38 PM
Subject: Re: [epilepsy] Re: phenobarbital?
I wonder if this is a "chicken or the egg" issue....AED's depress your nervous system, which makes you
depressed. I know if I increase my zonegran anymore, I will become so depressed, I was really surprised how
quickly the addition of one pill caused this. Or, do people with epilepsy tend to have depression simply
because of their situations? Loss of work/driving? Being tired? Were we depressed before a diagnosis of
epilepsy?
Just some thoughts!
elizabeth
----- Original Message -----
From: Matthew Ford
To: epilepsy@yahoogroups.com
Sent: Sunday, January 01, 2012 1:43 PM
Subject: [epilepsy] Re: phenobarbital?
The US Food and Drug Administration recently issued a warning about AEDs and
suicidality. Pharmaceutical companies performed placebo-controlled trials
with 11 different AEDs, and a 3 year meta-analysis was performed.
With almost 2800 patients in the AED drug arms and 1600 in the placebo arms,
they found that suicidal ideation or attemptive behaviour in the AED drug
arms was 41.8%, and were significantly increased for patients on lamotrigine
(29% of patients in these studies were taking lamotrigine for epilepsy) and
for topiramate (11% of patients were taking topiramate for epilepsy).
Suicidal Ideation significantly increased in patients taking AEDs for
epilepsy, and altogether, there were 34 completed and 1,668 attempted
suicides in people taking AEDs and yet none in the placebo arms.
A study in Iceland investigated Adults and Children over 10 years of age who
developed unprovoked seizures within a period of just over 3 years.
Psychiatric assessments were performed using telephone interviews to arrive
at Diagnostic and Statistical Manual of Mental Disorders-IV diagnoses.
With 324 patients with new onset of seizures and 647 controlled, a history
of major depression was almost twice as common in those with seizures and a
history of a suicide attempt was five times as common in those with seizures
Conclusion
It seems conclusive that the risk of suicide is increased in people with epilepsy, but further studies are
needed to identify those more at risk. Claims have been made that suitable treatment may prevent suicides in
people with epilepsy and other neurological disorders, but these need to be substantiated.
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[Non-text portions of this message have been removed]
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