Re: the Wikipedia article on LPL:
Pathology
Lipoprotein lipase deficiency leads to hypertriglyceridemia (elevated levels of triglycerides in the bloodstream).[23] In mice, overexpression of LPL has been shown to affect insulin response[24][25] and to promote obesity.[19]
A high tissue LPL response to a high-carbohydrate diet may predispose toward fat gain. One study reported that subjects gained more body fat over the next four years if, after following a high-carbohydrate diet and partaking of a high-carbohydrate meal, they responded with an increase in adipose tissue LPL activity per adipocyte, or a decrease in skeletal muscle LPL activity per gram of tissue.[26]
This makes sense to me in what I generally experience. High carb diets, even when calorie controlled make me gain weight, whether I'm fasting or not.
-Rick
---In fast5@yahoogroups.com, <bherring@...> wrote : There's a decent summary about LPL in Wikipedia, which itself is no authority, but the references listed there support the Wikipedia content. For example, the 1992 paper by Braun and Severson states that "fasting results in a reduction in LPL activity in adipose tissue but an increase in cardiac tissue; as a result, fatty acids are diverted away from storage in adipose tissue to meet the metabolic demands of the heart under conditions of caloric deprivation." Basically, the body is doing what makes sense — freeing up the circulating fat where it's needed for fuel. When carbs are abundant and insulin is up, adipose LPL gets to work..so it's stored, which again makes sense.
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