Wednesday, November 4, 2009

RE: [epilepsy] Tranxene

Jason,

Thanks for responding so soon and thanks for all the info.

I think what I meant to say is that basically how soon will we see seizures start to simmer down. Sarah now has simple to partial complex seizures. She was born with Infantile Spasms, had a right functional hemi when she was 8 months old. Seizures come and go and change.

I read your post on Keppra.... for her it was the drug from HE*&... in a huge way. She was on it twice for a short time and never again. She was also on Trileptica good but depleted her of sodium... I now noticed she enjoys huggs and kisses more now that she is off of it. She tried Banzel and gave her a rash at the same time Dialanta which put her in the hospital for 3 weeks due to bringing her platlets down.

Now just Topomax and Tranxene. She has been on Tranxene for just under 24 hours and seems good... maybe tired some.... but better. We see her now has happy and silly but not as "drunk" acting as when she was on Banzel which I think caused her to be so.

From what I have read, Tranxene similar to Klonipin which she takes at night.... make her a bit mellow. Trust me I would rather take this that the aggressive behavior she has had on the Keppra. Its not fair for her to feel so upset all the time and not have seizures. I hope these meds work.

Thanks again!

Victoria


To: epilepsy@yahoogroups.com
From: tiscione@gmail.com
Date: Wed, 4 Nov 2009 10:43:36 -0800
Subject: Re: [epilepsy] Tranxene

Not like Keppra at all. It's one of the benzodiazepines.

Official name of Tranxene is clorazepate; others are lorazepam (Ativan),
diazepam (valium), alprazolam (xanax), etc etc. It's the one I think that
doesn't end in "azepam".

They all show cross tolerance; only lorazepam and (I've heard) diazepam are
used for epilepsy. In general these are best used during the short term. I
take Ativan during emergencies but usually try to lay off of it. None of
these drugs are any "fun" but they are addictive. Ativan especially is
supposed to have a high addictive potential.

I don't know why your doctor is confused about this- these drugs (Ativan,
Tranxene, mayyyybe diazepam, but not Xanax) control seizures immediately. In
fact their seizure control starts out really strong and only decays a bit
with frequent usage.

I used to work at a company that made clorazepate tablets. (A generic of
Tranxene, not Tranxene itself.) It's a controlled substance so if we even
dropped some on the floor we had to carefully dust it up, weigh it, enter
the weight into a specialized notebook, and then dump it into a bottle
labeled "clorazepate waste" which also got weighed. The DEA examined the
notebooks and if there was any discrepancy they came in demanding to be
shown where it was. I can only imagine what would happen if we were making
vicodin.

Keppra comes flying in from an entirely different ballpark. Don't worry
about similarity to Keppra (take it from one who's been there).

Jason

On Wed, Nov 4, 2009 at 6:06 AM, Victoria Zicafoose <thezfamily04@msn.com>wrote:

>
> Hi,
> Anyone here of Tranxene and if your taking it.... how does it make you
> feel??? My little girl is starting it and it says it can effect behavior and
> if it is like Keppra... the medicine from HE*&.... then I dont want her on
> it. Also....how long does it take for medicine to start controlling
> seizures.... a few days, a week???? Doctor is not sure really.
> Victoria
>

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